Adult Recommended single dose: 10 mg repeated up to tds. Max: 30 mg daily. Duration: 5 days. Prevention of delayed CINV Recommended dose: 0.1-0.15 mg/kg repeated up to tds. Max: 0.5 mg/kg daily. Paed 15-18 yr, >60 kg 10 mg up to tds, 9-15 yr, 30-60 kg 5 mg up to tds, 5-9 yr, 20-29 kg 2.5 mg up to tds, 3-5 yr, 15-19 kg 2 mg up to tds, 1-3 yr, 10-14 kg 1 mg up to tds. Duration: 5 days.
Should be taken on an empty stomach: Take 30 min before meals.
Contraindications
Hypersensitivity. GI haemorrhage, mechanical obstruction or GI perforation. Confirmed or suspected pheochromocytoma due to risk of severe HTN episodes. History of neuroleptic- or metoclopramide-induced tardive dyskinesia. Epilepsy. Parkinson's disease. Known history of methemoglobinemia w/ metoclopramide or NADH cytochrome-b5 deficiency. Combination w/ l-dopa or dopaminergic agonists. Childn <1 yr.
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